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Blood cell markers that can predict the long-term outcomes of patients with colorectal cancer

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  • Hironori Mizuno
  • Norihiro Yuasa
  • Eiji Takeuchi
  • Hideo Miyake
  • Hidemasa Nagai
  • Yuichiro Yoshioka
  • Kanji Miyata

Abstract

Objectives: To identify blood cell markers that predict the long-term outcomes of patients with colorectal cancer. Methods: Data from 892 stage II and III colorectal cancer patients who underwent R0 resection were included. We analyzed the correlations of the preoperative blood data, previously reported prognostic indices, and clinicopathologic factors with the long-term outcomes, such as relapse-free survival and overall survival, using univariate and multivariate analyses. Results: Multivariate analysis showed that tumor location, stage, mean corpuscular volume, neutrophil-to-lymphocyte ratio, and lymphocyte-to- monocyte ratio were significantly correlated with relapse-free survival. A mean corpuscular volume ≥80.5 fL, neutrophil-to-lymphocyte ratio ≥5.5, and lymphocyte-to- monocyte ratio

Suggested Citation

  • Hironori Mizuno & Norihiro Yuasa & Eiji Takeuchi & Hideo Miyake & Hidemasa Nagai & Yuichiro Yoshioka & Kanji Miyata, 2019. "Blood cell markers that can predict the long-term outcomes of patients with colorectal cancer," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-15, August.
    • Handle: RePEc:plo:pone00:0220579
    DOI: 10.1371/journal.pone.0220579
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    1. Yasuhito Iseki & Masatsune Shibutani & Kiyoshi Maeda & Hisashi Nagahara & Hiroshi Ohtani & Kenji Sugano & Tetsuro Ikeya & Kazuya Muguruma & Hiroaki Tanaka & Takahiro Toyokawa & Katsunobu Sakurai & Kos, 2015. "Impact of the Preoperative Controlling Nutritional Status (CONUT) Score on the Survival after Curative Surgery for Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-13, July.
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