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Perturbations of pulsatile hemodynamics and clinical outcomes in patients with acute heart failure and reduced, mid-range or preserved ejection fraction

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Listed:
  • Wei-Ming Huang
  • Shih-Hsien Sung
  • Wen-Chung Yu
  • Hao-Min Cheng
  • Chi-Jung Huang
  • Chao-Yu Guo
  • Dai-Yin Lu
  • Ching-Wei Lee
  • Chen-Huan Chen

Abstract

Background: Heart failure with mid-range ejection fraction (HFmrEF) has been proposed as a new phenotype of heart failure. We therefore investigated the pulsatile hemodynamic characteristics and outcomes in patients with HFmrEF, in comparison with those with reduced (HFrEF) or preserved (HFpEF) ejection fraction. Methods: The study was composed of two cohorts of patients hospitalized due to acute heart failure. Pulsatile hemodynamic measures, including carotid-femoral pulse wave velocity (cf-PWV), carotid pulse pressure (cPP), amplitude of the backward pressure wave (Pb) and carotid augmentation index (cAIx), were recorded on admission and before discharge in Cohort A (n = 230, mean age 69.9 ±15.4 years), and long-term follow-up was performed in Cohort B (n = 2677, mean age 76.3 ± 33.4 years). Results: In Cohort A, patients with HFmrEF had persistently greater cf-PWV, cPP, Pb, and cAI than those with HFrEF, both on admission and before discharge. In contrast, patients with HFmrEF and HFpEF had similar pulsatile hemodynamic characteristics. In cohort B, patients with HFmrEF and HFrEF had similar three-year mortality rates and both were significantly higher than that in patients with HFpEF (both P values

Suggested Citation

  • Wei-Ming Huang & Shih-Hsien Sung & Wen-Chung Yu & Hao-Min Cheng & Chi-Jung Huang & Chao-Yu Guo & Dai-Yin Lu & Ching-Wei Lee & Chen-Huan Chen, 2019. "Perturbations of pulsatile hemodynamics and clinical outcomes in patients with acute heart failure and reduced, mid-range or preserved ejection fraction," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0220183
    DOI: 10.1371/journal.pone.0220183
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