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Meibomian gland dropout rate as a method to assess meibomian gland morphologic changes during use of preservative-containing or preservative-free topical prostaglandin analogues

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  • Sang Yeop Lee
  • Kwanghyun Lee
  • Chan Keum Park
  • Sangah Kim
  • Hyoung Won Bae
  • Gong Je Seong
  • Chan Yun Kim

Abstract

Purpose: To investigate the usefulness of meibomian gland (MG) dropout rate in the evaluation of MG morphological change associated with the use of prostaglandin for glaucoma treatment through the association between MG and the ocular surface parameters and medication duration and presence of preservative. Methods: This cross-sectional study was conducted on 88 eyes of 88 patients who were diagnosed with glaucoma and used only Tafluprost as treatment. The patients were divided into four “user” groups: 1) 23 patients used preservative-free (PF) Tafluprost for 6 months; 2) 21 patients used preservative-containing (PC) Tafluprost for 6 months; 3) 23 patients used PF-Tafluprost for 24 months; 4) 21 patients used PC-Tafluprost for 24 months. Ocular surface parameters and the MG condition, including MG dropout rate and meiboscale, were evaluated. Multiple regression was used to identify associations. Results: There were significant differences in age (p = 0.003), tear breakup time (p = 0.016), lid margin abnormality (p = 0.016), expressibility (p = 0.039), meiboscale (p

Suggested Citation

  • Sang Yeop Lee & Kwanghyun Lee & Chan Keum Park & Sangah Kim & Hyoung Won Bae & Gong Je Seong & Chan Yun Kim, 2019. "Meibomian gland dropout rate as a method to assess meibomian gland morphologic changes during use of preservative-containing or preservative-free topical prostaglandin analogues," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0218886
    DOI: 10.1371/journal.pone.0218886
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