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Discordance of epidermal growth factor receptor mutation between primary lung tumor and paired distant metastases in non-small cell lung cancer: A systematic review and meta-analysis

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Listed:
  • Chia Ching Lee
  • Yu Yang Soon
  • Char Loo Tan
  • Wee Yao Koh
  • Cheng Nang Leong
  • Jeremy Chee Seong Tey
  • Ivan Weng Keong Tham

Abstract

Purpose: To evaluate the rate of discordance of epidermal growth factor receptor (EGFR) mutation between primary lung tumor and paired distant metastases in non-small-cell lung cancer (NSCLC). Methods: We performed a meta-analysis of 17 studies (518 cases) assessing discordance rates of EGFR mutation in primary tumors and paired distant metastases. We performed subgroup analyses based on EGFR mutation status in primary tumor (mutant or wildtype), site of distant metastasis (bone, central nervous system (CNS) or lung/ pleural), methods of testing (direct sequencing or allele-specific testing) and timing of metastasis (synchronous or metachronous). Results: The overall discordance rate in EGFR mutation was low at 10.36% (95% CI = 4.23% to 18.79%) and varied widely between studies (I2 = 83.18%). The EGFR discordance rate was statistically significantly higher in bone metastases (45.49%, 95% CI = 14.13 to 79.02) than CNS (17.26%, 95% CI = 7.64 to 29.74; P = 0.002) and lung/ pleural metastases (8.17%, 95% CI = 3.35 to 14.85; P

Suggested Citation

  • Chia Ching Lee & Yu Yang Soon & Char Loo Tan & Wee Yao Koh & Cheng Nang Leong & Jeremy Chee Seong Tey & Ivan Weng Keong Tham, 2019. "Discordance of epidermal growth factor receptor mutation between primary lung tumor and paired distant metastases in non-small cell lung cancer: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0218414
    DOI: 10.1371/journal.pone.0218414
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