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Investigating the potential of Zernike polynomials to characterise spatial distribution of macular pigment

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  • Piers Allen
  • Antonio Calcagni
  • Anthony G Robson
  • Ela Claridge

Abstract

It has been postulated that particular patterns of macular pigment (MP) distribution may be associated with the risk for eye diseases such as age-related macular degeneration (AMD). This work investigates the potential of Zernike polynomials (ZP) to characterise the level and distribution of MP, and their suitability as a representation for analysis of the effects of age and AMD on MP patterns. As the case study, MP distribution maps computed using an experimental method based on fundus reflectance (MRIA) were obtained for ninety volunteers representing three groups: under-fifty without AMD, fifty and over without AMD, and fifty and over with AMD. ZP with 105 coefficients were fitted to the maps using least-squares optimisation and found to represent MP maps accurately (RMSE

Suggested Citation

  • Piers Allen & Antonio Calcagni & Anthony G Robson & Ela Claridge, 2019. "Investigating the potential of Zernike polynomials to characterise spatial distribution of macular pigment," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-19, May.
    • Handle: RePEc:plo:pone00:0217265
    DOI: 10.1371/journal.pone.0217265
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