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Segregated neural explants exhibit co-oriented, asymmetric, neurite outgrowth

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  • David B Pettigrew
  • Curtis B Dobson
  • Lori G Isaacson
  • Eric C Leuthardt
  • Heather N Lilley
  • Georgette L Suidan
  • Keith A Crutcher

Abstract

Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a) differences in neurite length and, b) differences in neurite morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism(s) of the asymmetry and its co-orientation are not known but appear to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This emergent behavior may be similar to the community effect described in other cell types. If a similar phenomenon exists in the embryo, or in maturity, it may contribute to the establishment of proper orientation of neurite outgrowth during development and/or injury-induced neuronal plasticity.

Suggested Citation

  • David B Pettigrew & Curtis B Dobson & Lori G Isaacson & Eric C Leuthardt & Heather N Lilley & Georgette L Suidan & Keith A Crutcher, 2019. "Segregated neural explants exhibit co-oriented, asymmetric, neurite outgrowth," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-18, September.
    • Handle: RePEc:plo:pone00:0216263
    DOI: 10.1371/journal.pone.0216263
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