IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0214907.html
   My bibliography  Save this article

Sex differences in left ventricular afterload and diastolic function are independent from the aortic size

Author

Listed:
  • Hidemi Sorimachi
  • Koji Kurosawa
  • Kuniko Yoshida
  • Masaru Obokata
  • Takashi Noguchi
  • Minoru Naka
  • Shoichi Tange
  • Masahiko Kurabayashi
  • Kazuaki Negishi

Abstract

Background: Women have a greater risk of heart failure with preserved ejection fraction (HFPEF) than men do, yet the basis for this disparity remains unclear. Greater arterial stiffness and afterload causes left ventricular (LV) diastolic dysfunction, a central mechanism of HFPEF. Because of smaller body habitus, previous reports have used body surface area as a surrogate of the size of the aorta. We performed a comprehensive hemodynamic evaluation of elderly patients with preserved EF and evaluated sex differences in the associations between LV function and afterload, before and after adjusting for the aortic sizes. Methods and results: Four hundred and forty-three patients (mean age: 73 years, 169 women) who underwent clinically indicated echocardiography and computed tomography (CT) were identified. Linear regression analyses were performed to assess the independent contributions of sex to and its interaction with LV function before and after adjusting for CT-derived aortic length and volume. Although blood pressures were similar between the sexes, women had greater arterial elastance, lower arterial compliance, and greater LV ejection fraction (all p

Suggested Citation

  • Hidemi Sorimachi & Koji Kurosawa & Kuniko Yoshida & Masaru Obokata & Takashi Noguchi & Minoru Naka & Shoichi Tange & Masahiko Kurabayashi & Kazuaki Negishi, 2019. "Sex differences in left ventricular afterload and diastolic function are independent from the aortic size," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-18, April.
    • Handle: RePEc:plo:pone00:0214907
    DOI: 10.1371/journal.pone.0214907
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214907
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0214907&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0214907?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0214907. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.