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Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection

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Listed:
  • Mi Young Jeon
  • Hye Soo Kim
  • Tae Seop Lim
  • Dai Hoon Han
  • Beom Kyung Kim
  • Jun Yong Park
  • Do Young Kim
  • Sang Hoon Ahn
  • Gi Hong Choi
  • Jin Sub Choi
  • Kwang-Hyub Han
  • Seung Up Kim

Abstract

Background/Aims: It is important to identify patients who are refractory to transarterial chemoembolization (TACE), which is performed for the treatment of hepatocellular carcinoma (HCC). We investigated the predictors of poor treatment outcomes in patients with recurrent HCC treated who were treated with TACE after curative resection. Methods: 428 patients with recurrent HCC after curative resection who were treated with TACE were enrolled. Results: The median age of the study population was 59.2 years. On multivariate analysis, ≥2 TACE procedures within 6 months (hazard ratio [HR] = 1.898), and the des-gamma carboxyprothrombin level (HR = 1.000) independently predicted the progression to Barcelona Clinic Liver Cancer (BCLC) stage C in patients with BCLC stage 0-B HCC (both P

Suggested Citation

  • Mi Young Jeon & Hye Soo Kim & Tae Seop Lim & Dai Hoon Han & Beom Kyung Kim & Jun Yong Park & Do Young Kim & Sang Hoon Ahn & Gi Hong Choi & Jin Sub Choi & Kwang-Hyub Han & Seung Up Kim, 2019. "Refractoriness to transarterial chemoembolization in patients with recurrent hepatocellular carcinoma after curative resection," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0214613
    DOI: 10.1371/journal.pone.0214613
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