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The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis

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  • Zhong Rui
  • Chen Qingling
  • Zhang Xinyue
  • Zhang Xin
  • Lin Weihong

Abstract

Background: Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson’s disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controversial. Objective: This systematic review and meta-analysis aimed to identify the possible related factors of SB in PD. Methods: We searched PubMed, EMBASE and WanFang databases to collect eligible articles. We calculated pooled estimates of odds ratios (ORs) or the mean deviation (MD) with 95% confidence intervals. Results: We found 3 related factors associated with SB: the duration of PD (MD 1.22, 95% CI: 0.21–2.23), sleep efficiency (MD -4.48,95% CI: -7.24- -2.44), and on-state MDS-UPDRS-Ⅲ total score (MD 3.05, 95% CI: 0.53–5.57). Conclusion: PD patients with SB are more likely to have a long duration of PD, a low sleep efficiency and a high MDS-UPDRS-Ⅲ total score. Our work helps obtain a better understanding of sleep SB in PD and its underlying mechanisms. More studies need to be conducted to evaluate the associations between clinical factors in PD and the SB phenomenon.

Suggested Citation

  • Zhong Rui & Chen Qingling & Zhang Xinyue & Zhang Xin & Lin Weihong, 2019. "The related factors of sleep benefit in Parkinson’s disease: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0212951
    DOI: 10.1371/journal.pone.0212951
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