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The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV

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  • Giovanni Guaraldi
  • Stefano Zona
  • Ana Rita Silva
  • Marianna Menozzi
  • Giovanni Dolci
  • Jovana Milic
  • Federica Carli
  • Cristina Mussini

Abstract

Objective: To investigate the association between current CD4+ T-cell count and CD4/CD8+ ratio with severity of frailty among people aging with HIV. Methods: Cross-sectional observational study analysing data from all study visits in the ongoing prospective Modena HIV Metabolic Clinic Cohort between 2006 and 2015. Frailty severity was assessed using a frailty index (FI). We visualized the relationships between frailty index score and current CD4 cell count and CD4/CD8 ratio on two different curves adjusted for age, sex, and duration of HIV infection. Results: Frailty index scores exhibited an inverse relationship with current CD4 count, up to 900 cells/μL. The CD4/CD8 ratio was inversely correlated with frailty index both below and above the cut-off of 900 CD4 cells/μL. Conclusions: Frailty in PLWH is inversely associated with both immune-activation, depicted by CD4/CD8 ratio and immune-deficit depicted by CD4 count. The first association shows a linear shape while the second shows a hook-shape with a turning point at 900 cells. Above this cut off level CD4 do not represent a significant risk factor for frailty.

Suggested Citation

  • Giovanni Guaraldi & Stefano Zona & Ana Rita Silva & Marianna Menozzi & Giovanni Dolci & Jovana Milic & Federica Carli & Cristina Mussini, 2019. "The dynamic association between Frailty, CD4 and CD4/CD8 ratio in people aging with HIV," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0212283
    DOI: 10.1371/journal.pone.0212283
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