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The role of surgery in stage I to III small cell lung cancer: A systematic review and meta-analysis

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  • Tingting Liu
  • Zihao Chen
  • Jun Dang
  • Guang Li

Abstract

Background: The role of surgery in treating small cell lung cancer (SCLC) remains controversial. This meta-analysis aims to determine whether surgical-based treatment improves survival in comparison to radiotherapy, chemotherapy, and chemoradiotherapy for stage I to III SCLC. Methods: PubMed, PubMed Central, EMBASE, Web of Science, and Cochrane Library were searched for relevant articles. The main outcome were overall survival (OS), reported as hazard ratios (HRs), and 95% confidence intervals (CIs). Results: Two randomized control trials (RCTs) and 13 retrospective studies that included a total of 41,483 patients were eligible. Surgical resection significantly improved OS when compared to non-surgical treatment in retrospective studies (HR = 0.56, 95% CI: 0.49–0.64, P

Suggested Citation

  • Tingting Liu & Zihao Chen & Jun Dang & Guang Li, 2018. "The role of surgery in stage I to III small cell lung cancer: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0210001
    DOI: 10.1371/journal.pone.0210001
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