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Better treatment outcomes in patients with actively treated therapy-related myeloid neoplasms harboring a normal karyotype

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  • Sang-A Kim
  • Junshik Hong
  • Woo Chan Park
  • Dong-Yeop Shin
  • Youngil Koh
  • Inho Kim
  • Dong Soon Lee
  • Sung-Soo Yoon

Abstract

We analyzed treatment outcomes and prognostic factors in adult patients with therapy-related myeloid neoplasms (t-MNs) to select patients who would be benefited by active anticancer treatment. After excluding 18 patients who received palliative care only and 13 patients with acute promyelocytic leukemia, 72 t-MN patients (45 with acute myeloid leukemia and 27 with myelodysplastic syndrome) were retrospectively evaluated. Among them, 10 (13.9%), 32 (44.4%), and 30 patients (41.7%) had favorable, intermediate- and adverse-risk cytogenetics, respectively. Among patients with intermediate-risk cytogenetics, patients with a normal karyotype (NK; N = 20) showed superior allogeneic stem cell transplantation-censored overall survival (AC-OS) and OS compared to those with non-NK-intermediate-risk cytogenetics (P

Suggested Citation

  • Sang-A Kim & Junshik Hong & Woo Chan Park & Dong-Yeop Shin & Youngil Koh & Inho Kim & Dong Soon Lee & Sung-Soo Yoon, 2018. "Better treatment outcomes in patients with actively treated therapy-related myeloid neoplasms harboring a normal karyotype," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0209800
    DOI: 10.1371/journal.pone.0209800
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