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Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis

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Listed:
  • Noel Pabalan
  • Raphael Enrique Tiongco
  • Jefferyl Kae Pandac
  • Noemi Anne Paragas
  • Shamar Lo Lasta
  • Nelven Gallego
  • Hamdi Jarjanazi
  • Maria Ruth Pineda-Cortel

Abstract

Background: Managing nephropathy associated with diabetes mellitus warrant investigation of relevant biomarkers in predicting this condition. Adiponectin (ADP) may hold promise as a biomarker for diabetic nephropathy (DN). In this study, we examine associations of ADP with DN by meta-analyzing relevant literature. We also examined the predictive potential of ADP and estimate progression of DN. Methods: Multi-database literature searches and serial omissions of articles yielded 13 studies for inclusion in the meta-analysis. We compared ADP levels between controls/ normoalbuminuria and cases with micro- and macroalbuminuria (MI and MA, respectively) as well as MI versus MA using standardized mean differences (SMD). Associations of ADP with DN were indicated with the P-value considered significant at ≤ 0.05. Subgrouping was based on diabetes type (1 and 2). Predictive potential of ADP was explored with AUC (area under the curve) derived from Receiver Operating Characteristic curve analysis. Results and conclusion: At high P-values of

Suggested Citation

  • Noel Pabalan & Raphael Enrique Tiongco & Jefferyl Kae Pandac & Noemi Anne Paragas & Shamar Lo Lasta & Nelven Gallego & Hamdi Jarjanazi & Maria Ruth Pineda-Cortel, 2018. "Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-15, December.
    • Handle: RePEc:plo:pone00:0208905
    DOI: 10.1371/journal.pone.0208905
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