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A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

Author

Listed:
  • Makiko Taira
  • Minako Imamura
  • Atsushi Takahashi
  • Yoichiro Kamatani
  • Toshimasa Yamauchi
  • Shin-ichi Araki
  • Nobue Tanaka
  • Natalie R van Zuydam
  • Emma Ahlqvist
  • Masao Toyoda
  • Tomoya Umezono
  • Koichi Kawai
  • Masahito Imanishi
  • Hirotaka Watada
  • Daisuke Suzuki
  • Hiroshi Maegawa
  • Tetsuya Babazono
  • Kohei Kaku
  • Ryuzo Kawamori
  • The SUMMIT Consortium
  • Leif C Groop
  • Mark I McCarthy
  • Takashi Kadowaki
  • Shiro Maeda

Abstract

To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p

Suggested Citation

  • Makiko Taira & Minako Imamura & Atsushi Takahashi & Yoichiro Kamatani & Toshimasa Yamauchi & Shin-ichi Araki & Nobue Tanaka & Natalie R van Zuydam & Emma Ahlqvist & Masao Toyoda & Tomoya Umezono & Koi, 2018. "A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0208654
    DOI: 10.1371/journal.pone.0208654
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    References listed on IDEAS

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    1. Niina Sandholm & Rany M Salem & Amy Jayne McKnight & Eoin P Brennan & Carol Forsblom & Tamara Isakova & Gareth J McKay & Winfred W Williams & Denise M Sadlier & Ville-Petteri Mäkinen & Elizabeth J Swa, 2012. "New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes," PLOS Genetics, Public Library of Science, vol. 8(9), pages 1-13, September.
    2. Shiro Maeda & Masa-aki Kobayashi & Shin-ichi Araki & Tetsuya Babazono & Barry I Freedman & Meredith A Bostrom & Jessica N Cooke & Masao Toyoda & Tomoya Umezono & Lise Tarnow & Torben Hansen & Peter Ga, 2010. "A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes," PLOS Genetics, Public Library of Science, vol. 6(2), pages 1-9, February.
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