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Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study

Author

Listed:
  • Norma C Serrano
  • Doris Cristina Quintero-Lesmes
  • Silvia Becerra-Bayona
  • Elizabeth Guio
  • Mónica Beltran
  • María C Paez
  • Ricardo Ortiz
  • Wilmar Saldarriaga
  • Luis A Diaz
  • Álvaro Monterrosa
  • Jezid Miranda
  • Clara M Mesa
  • José E Sanin
  • German Monsalve
  • Frank Dudbridge
  • Aroon D Hingorani
  • Juan P Casas

Abstract

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Materials and methods: Design: A case-control study. Results: After adjusting for potential confounders in logistic regression models, the OR for pre-eclampsia was 0.80 (95% CI: 0.72, 0.90) for 1SD increase in log-folate, 1.16 (95%CI: 1.05, 1.27) for 1SD increase in log-homocysteine, and 1.10 (95%CI: 0.99, 1.22) for 1SD increase in log-vitamin B12. No interactions among the biomarkers were identified. Women who self-reported consumption of folic acid (1 mg/day) throughout their pregnancy had an adjusted OR for pre-eclampsia of 0.86 (95%CI: 0.67, 1.09) compared to women that reported no consumption of folic acid at any point during pregnancy. Conclusions: Maternal serum concentrations of folate were associated as a protective factor for pre-eclampsia while concentrations of homocysteine were associated as a risk factor. No association between maternal vitamin B12 concentrations and preeclampsia was found.

Suggested Citation

  • Norma C Serrano & Doris Cristina Quintero-Lesmes & Silvia Becerra-Bayona & Elizabeth Guio & Mónica Beltran & María C Paez & Ricardo Ortiz & Wilmar Saldarriaga & Luis A Diaz & Álvaro Monterrosa & Jezid, 2018. "Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-15, December.
    • Handle: RePEc:plo:pone00:0208137
    DOI: 10.1371/journal.pone.0208137
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    References listed on IDEAS

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    1. Robert Clarke & Derrick A Bennett & Sarah Parish & Petra Verhoef & Mariska Dötsch-Klerk & Mark Lathrop & Peng Xu & Børge G Nordestgaard & Hilma Holm & Jemma C Hopewell & Danish Saleheen & Toshihiro Ta, 2012. "Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias," PLOS Medicine, Public Library of Science, vol. 9(2), pages 1-12, February.
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