Author
Listed:
- Marco Nassisi
- Elmira Baghdasaryan
- Tudor Tepelus
- Samuel Asanad
- Enrico Borrelli
- Srinivas R Sadda
Abstract
Purpose: To evaluate the topographic distribution of the choriocapillaris (CC) flow deficits in a population of healthy subjects. Methods: Using a swept-source optical-coherence tomography angiography (SS-OCTA) device, two repeated volume 6 x 6 mm and 3 x 3 mm scans were acquired in healthy subjects at the Doheny—UCLA Eye Centers. The en-face CC angiogram was binarized and analyzed for percentage of flow deficits (FD%) using a grid of progressive, concentric rings covering a circular area with a diameter of 2.5 mm (in the 3 x 3 mm scans) and 5 mm (in the 6 x 6 mm scans). The FD% for each ring was plotted against the distance from the fovea. The linear trendline of the resulting curve was analyzed and the slope (m) and intercept (q) were computed. Results: Seventy-five eyes of 75 subjects were enrolled and divided into three subgroups based on age (year ranges: 21–40, 41–60 and 61–80). For the entire cohort and within each subgroup, there was a significant association between distance from the fovea and FD% in both 3X3 mm and 6X6 mm scans, with flow deficits increasing with closer proximity to the foveal center. Age was a significant predictor for both m and q for both scan patterns, with older subjects showing a steeper slope. Conclusions: In SS-OCTA images, the topographic distribution of CC flow deficits varies with distance from the fovea and age. In particular, the FD% tends to decrease from the fovea towards the periphery, with a steeper decline with advancing age. These normal trends may need to be accounted for in future studies of the CC in disease.
Suggested Citation
Marco Nassisi & Elmira Baghdasaryan & Tudor Tepelus & Samuel Asanad & Enrico Borrelli & Srinivas R Sadda, 2018.
"Topographic distribution of choriocapillaris flow deficits in healthy eyes,"
PLOS ONE, Public Library of Science, vol. 13(11), pages 1-13, November.
Handle:
RePEc:plo:pone00:0207638
DOI: 10.1371/journal.pone.0207638
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