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Risk factors and outcomes of incidental parathyroidectomy in thyroidectomy: A systematic review and meta-analysis

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  • Binglong Bai
  • Zhiye Chen
  • Wuzhen Chen

Abstract

Introduction: Postoperative hypocalcemia is the most common complication of thyroidectomy. Incidental parathyroidectomy (IP) was thought to be associated with postoperative hypocalcemia. However, according to previous studies, the risk factors and clinical outcomes of IP remain controversial. Methods: Eligible studies were searched in databases including PubMed, Web of Science, and EMBASE from January 1990 to September 2017. Articles focusing on the relationship between IP and postoperative hypocalcemia were included. The risk of publication bias was assessed using Begg’s test and Egger’s regression asymmetry test. Pooled analysis was performed to evaluate the effect of IP on postoperative hypocalcemia and related risk factors. Sensitivity analysis was also conducted to test the stability of our results. The effects of hypocalcemia type, permanent definition, IP incidence, total thyroidectomy, and malignancy operation were also examined using a further subgroup analysis. Results: Thirty-five studies were finally included in the analysis after an exhaustive literature review. Pathology data demonstrate that incidental parathyroidectomy occurred in various locations: intrathyroidal (2.2–50.0%), intracapsular (16.7–40.0%) and extracapsular (15.7–81.1%) regions. Overall, the analysis found that malignancy (RR = 1.60, 95% CI: 1.27 to 2.02; p

Suggested Citation

  • Binglong Bai & Zhiye Chen & Wuzhen Chen, 2018. "Risk factors and outcomes of incidental parathyroidectomy in thyroidectomy: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0207088
    DOI: 10.1371/journal.pone.0207088
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