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Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study

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  • Catherine A Sullivan
  • Jose M Cacicedo
  • Iniya Rajendran
  • Devin W Steenkamp

Abstract

Aims: Increased proinsulin (PI) compared to C-peptide (CP) concentrations have been reported, both prior to type 1 diabetes mellitus (T1D) onset, as well as early in disease. In this pilot study, we sought to define the normal PI secretion in a healthy cohort and compare this to a local T1D cohort and a separate well-defined nationally representative T1D cohort with measurable CP. Methods: Thirteen healthy subjects and 12 T1D subjects with T1D >3 years from the local T1D cohort completed mixed meal tolerance tests (MMTT) with PI and CP measured over 90 and 240 minutes. The change in CP (maximum versus baseline, ΔCP) during MMTT in the T1D Exchange T1D cohort was stratified according to non-fasting PI concentrations, based on a fasting PI threshold, as defined by the healthy control group. Results: The maximum fasting PI in the control group was 6 pmol/L. Individuals from the T1D Exchange with a non-fasting PI ≥ 6 pmol/L had a lower ΔCP during a MMTT, compared to those with a PI

Suggested Citation

  • Catherine A Sullivan & Jose M Cacicedo & Iniya Rajendran & Devin W Steenkamp, 2018. "Comparison of proinsulin and C-peptide secretion in healthy versus long-standing type 1 diabetes mellitus cohorts: A pilot study," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0207065
    DOI: 10.1371/journal.pone.0207065
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