Author
Listed:
- Sarah Shalhoub
- Fahad Al-Hameed
- Yasser Mandourah
- Hanan H Balkhy
- Awad Al-Omari
- Ghaleb A Al Mekhlafi
- Ayman Kharaba
- Basem Alraddadi
- Abdullah Almotairi
- Kasim Al Khatib
- Ahmed Abdulmomen
- Ismael Qushmaq
- Ahmed Mady
- Othman Solaiman
- Abdulsalam M Al-Aithan
- Rajaa Al-Raddadi
- Ahmed Ragab
- Abdulrahman Al Harthy
- Eman Al Qasim
- Jesna Jose
- Ghassan Al-Ghamdi
- Laura Merson
- Robert Fowler
- Frederick G Hayden
- Yaseen M Arabi
Abstract
Background: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) leads to healthcare-associated transmission to patients and healthcare workers with potentially fatal outcomes. Aim: We aimed to describe the clinical course and functional outcomes of critically ill healthcare workers (HCWs) with MERS. Methods: Data on HCWs was extracted from a multi-center retrospective cohort study on 330 critically ill patients with MERS admitted between (9/2012–9/2015). Baseline demographics, interventions and outcomes were recorded and compared between survivors and non-survivors. Survivors were approached with questionnaires to elucidate their functional outcomes using Karnofsky Performance Status Scale. Findings: Thirty-Two HCWs met the inclusion criteria. Comorbidities were recorded in 34% (11/32) HCW. Death resulted in 8/32 (25%) HCWs including all 5 HCWs with chronic renal impairment at baseline. Non-surviving HCW had lower PaO2/FiO2 ratios 63.5 (57, 116.2) vs 148 (84, 194.3), p = 0.043, and received more ECMO therapy compared to survivors, 9/32 (28%) vs 4/24 (16.7%) respectively (p = 0.02).Thirteen of the surviving (13/24) HCWs responded to the questionnaire. Two HCWs confirmed functional limitations. Median number of days from hospital discharge until the questionnaires were filled was 580 (95% CI 568, 723.5) days. Conclusion: Approximately 10% of critically ill patients with MERS were HCWs. Hospital mortality rate was substantial (25%). Patients with chronic renal impairment represented a particularly high-risk group that should receive extra caution during suspected or confirmed MERS cases clinical care assignment and during outbreaks. Long-term repercussions of critical illness due to MERS on HCWs in particular, and patients in general, remain unknown and should be investigated in larger studies.
Suggested Citation
Sarah Shalhoub & Fahad Al-Hameed & Yasser Mandourah & Hanan H Balkhy & Awad Al-Omari & Ghaleb A Al Mekhlafi & Ayman Kharaba & Basem Alraddadi & Abdullah Almotairi & Kasim Al Khatib & Ahmed Abdulmomen , 2018.
"Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study,"
PLOS ONE, Public Library of Science, vol. 13(11), pages 1-12, November.
Handle:
RePEc:plo:pone00:0206831
DOI: 10.1371/journal.pone.0206831
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