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HAVCR1 expression might be a novel prognostic factor for gastric cancer

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  • Lingling Liu
  • Zhaoquan Song
  • Yingchun Zhao
  • Chao Li
  • Hua Wei
  • Ji Ma
  • Yaowu Du

Abstract

Hepatitis A virus cellular receptor 1 (HAVCR1), which is also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a TIM gene family member. In this study, we aimed to characterize the expression profile of HAVCR1 in GC, its prognostic value and the potential epigenetic mechanism leading to its dysregulation. Bioinformatic analysis was performed by using genomic, clinicopathological and survival data in the human protein atlas (HPA) and the Cancer Genome Atlas (TCGA). Results showed that HAVCR1 was significantly upregulated at the mRNA and protein level in GC tissues compared to the adjacent normal tissues. In addition, HAVCR1 upregulation was an independent indicator of shorter OS (HR: 1.698, 95%CI: 1.221–2.361, p = 0.002), after adjustment of older age, differentiation status, pathological stages and the presence of residual tumor and was also an independent indicator of shorter RFS (HR: 2.577, 95%CI: 1.583–4.197, p

Suggested Citation

  • Lingling Liu & Zhaoquan Song & Yingchun Zhao & Chao Li & Hua Wei & Ji Ma & Yaowu Du, 2018. "HAVCR1 expression might be a novel prognostic factor for gastric cancer," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0206423
    DOI: 10.1371/journal.pone.0206423
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