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Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF

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  • Barbara Lawrenz
  • Junard Sibal
  • Nicolas Garrido
  • Emmanuel Abu
  • Alliza Jean
  • Laura Melado
  • Human M Fatemi

Abstract

In recent years there is increasing evidence that elevated progesterone levels during ovarian stimulation for IVF / ICSI have a negative impact on the ART-outcome. However, different progesterone assays were used in the previous studies and different assays might produce varying results. This retrospective study evaluated the reproducibility and reliability of different progesterone assays with a special focus on progesterone levels below 1.5 ng/ml, as this range is crucial for early detection of progesterone rise during ovarian stimulation for IVF. A total of 413 blood samples were categorized in different progesterone ranges and whether they were retrieved on the day of final oocyte maturation and the results were compared regarding their reproducibility and reliability. To compare the reproducibility between the different progesterone assays, the Intraclass Correlation Coefficient (ICC) was calculated and interpretation of the ICC results was done according to Cicchetti, ranging from poor to excellent. The correlation of the assays was excellent when all samples were compared including samples retrieved on day of final oocyte maturation, however in the ranges of progesterone levels 1.0 ng/ml to

Suggested Citation

  • Barbara Lawrenz & Junard Sibal & Nicolas Garrido & Emmanuel Abu & Alliza Jean & Laura Melado & Human M Fatemi, 2018. "Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0206098
    DOI: 10.1371/journal.pone.0206098
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    References listed on IDEAS

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    1. Bo Huang & Xinling Ren & Li Wu & Lixia Zhu & Bei Xu & Yufeng Li & Jihui Ai & Lei Jin, 2016. "Elevated Progesterone Levels on the Day of Oocyte Maturation May Affect Top Quality Embryo IVF Cycles," PLOS ONE, Public Library of Science, vol. 11(1), pages 1-8, January.
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