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Relationship between the rate of change in lamina cribrosa depth and the rate of retinal nerve fiber layer thinning following glaucoma surgery

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  • Patrycja Krzyżanowska-Berkowska
  • Karolina Czajor
  • Iwona Helemejko
  • D Robert Iskander

Abstract

Purpose: To assess whether lamina cribrosa depth (LCD) reduction and the rate of change in LCD over time (ΔLCD/Δt) is associated with retinal nerve fiber layer (RNFL) thickness and the rate of RNFL thinning over time (ΔRNFL/Δt) to test the hypothesis that, in a long term, RNFL thinning occurs irrespectively to the displacement of the lamina cribrosa following glaucoma surgery. Methods: Twenty-nine primary open-angle glaucoma patients underwent glaucoma surgery. Sixteen patients underwent trabeculectomy and 13 patients undertook non-penetrating deep sclerectomy. Images of optic nerve head using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging technology were obtained preoperatively, at one-, three-, six-month and follow-up postoperative visit from 12 to 29 months after surgery (1pv, 3pv, 6pv, and FUpv, respectively). Correspondingly, measurements of the circumpapillary RNFL thickness were acquired. Results: Intraocular pressure decreased from 24.0±8.9 to 10.9±3.9mmHg at 6pv (P

Suggested Citation

  • Patrycja Krzyżanowska-Berkowska & Karolina Czajor & Iwona Helemejko & D Robert Iskander, 2018. "Relationship between the rate of change in lamina cribrosa depth and the rate of retinal nerve fiber layer thinning following glaucoma surgery," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-15, November.
    • Handle: RePEc:plo:pone00:0206040
    DOI: 10.1371/journal.pone.0206040
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