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Effect of adherence to growth hormone treatment on 0–2 year catch-up growth in children with growth hormone deficiency

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  • Paula van Dommelen
  • Ekaterina Koledova
  • Jan M Wit

Abstract

Background: Quantifying the association between adherence and the growth response to growth hormone (GH) treatment is hampered by suboptimal methods of measuring adherence, confounders associated with the growth response, and restriction of the outcome parameters to yearly growth velocities. Aim: To investigate the effect of adherence on the two-year growth response to GH treatment in prepubertal children with idiopathic isolated growth hormone deficiency (GHD) participating in the easypod connect observational study (ECOS), a 5-year, Phase IV open-label study to continuously assess real-world adherence via the easypod electronic drug-delivery device. Patients and methods: Outcome measures were change in height standard deviation score (ΔHSDS), index of responsiveness (IoR), and parameters of two catch-up growth (CUG) curve functions (monomolecular growth curve and second degree polynomial) with adj-HSDS (HSDS minus Target height (TH) SDS) as dependent variable. Inclusion criteria were GHD, naïve to GH treatment, known TH, age

Suggested Citation

  • Paula van Dommelen & Ekaterina Koledova & Jan M Wit, 2018. "Effect of adherence to growth hormone treatment on 0–2 year catch-up growth in children with growth hormone deficiency," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0206009
    DOI: 10.1371/journal.pone.0206009
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