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Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

Author

Listed:
  • Alessandro Rabiolo
  • Francesco Gelormini
  • Riccardo Sacconi
  • Maria Vittoria Cicinelli
  • Giacinto Triolo
  • Paolo Bettin
  • Kouros Nouri-Mahdavi
  • Francesco Bandello
  • Giuseppe Querques

Abstract

Purpose: To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. Methods: Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated. Results: Healthy eyes exhibited higher vessel density values in all plexuses compared to diseased eyes regardless of the algorithm used (p

Suggested Citation

  • Alessandro Rabiolo & Francesco Gelormini & Riccardo Sacconi & Maria Vittoria Cicinelli & Giacinto Triolo & Paolo Bettin & Kouros Nouri-Mahdavi & Francesco Bandello & Giuseppe Querques, 2018. "Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-20, October.
  • Handle: RePEc:plo:pone00:0205773
    DOI: 10.1371/journal.pone.0205773
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    Cited by:

    1. Jan Henrik Terheyden & Maximilian W M Wintergerst & Peyman Falahat & Moritz Berger & Frank G Holz & Robert P Finger, 2020. "Automated thresholding algorithms outperform manual thresholding in macular optical coherence tomography angiography image analysis," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-12, March.

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