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Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence

Author

Listed:
  • Muhammad Miftahussurur
  • Dalla Doohan
  • Iswan Abbas Nusi
  • Pangestu Adi
  • Yudith Annisa Ayu Rezkitha
  • Langgeng Agung Waskito
  • Kartika Afrida Fauzia
  • Taufan Bramantoro
  • Ummi Maimunah
  • Husin Thamrin
  • Safitri Indah Masithah
  • Sukadiono Sukadiono
  • Tomohisa Uchida
  • Maria Inge Lusida
  • Yoshio Yamaoka

Abstract

The association between gastroesophageal reflux disease (GERD) prevalence and its risk factors in an area with low Helicobacter pylori prevalence is important to clarify. We analyzed the prevalence of GERD and risk factors in an area of Indonesia with low prevalence of H. pylori infection. We recruited 104 dyspeptic patients who underwent endoscopy in Surabaya. Patients were diagnosed with GERD based on the Los Angeles classification. We evaluated gastric biopsy specimens and measured serum pepsinogen levels. Interleukin polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism. Of 104 patients, 56 (53.8%) were endoscopically found to have GERD, with most categorized as grade A; 48 (46.2%) were classified as non-GERD. Higher economic status, smoking, and a history of proton-pump inhibitor use significantly increased the risk of GERD. GERD Questionnaire scores showed a positive correlation with GERD (P

Suggested Citation

  • Muhammad Miftahussurur & Dalla Doohan & Iswan Abbas Nusi & Pangestu Adi & Yudith Annisa Ayu Rezkitha & Langgeng Agung Waskito & Kartika Afrida Fauzia & Taufan Bramantoro & Ummi Maimunah & Husin Thamri, 2018. "Gastroesophageal reflux disease in an area with low Helicobacter pylori infection prevalence," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-15, November.
    • Handle: RePEc:plo:pone00:0205644
    DOI: 10.1371/journal.pone.0205644
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