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Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients

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  • Regina Juanbeltz
  • Iván Martínez-Baz
  • Ramón San Miguel
  • Silvia Goñi-Esarte
  • Juan Manuel Cabasés
  • Jesús Castilla

Abstract

Background: Direct-acting antivirals (DAA) have demonstrated high efficacy to achieve sustained virological response (SVR) in chronic hepatitis C patients. We aim to assess the change in health-related quality of life (HRQoL) among patients successfully treated, and to identify predictors of this variation. Methods: In a prospective observational study, patients with chronic hepatitis C who started DAA therapy between May 2016 and April 2017 completed the EQ-5D-5L questionnaire at baseline and 12 weeks after the end of therapy before knowing the virological result. Analysis included all patients with SVR. Results: Median baseline EQ-5D-5L scores of the 206 enrolled patients were 0.857 utility and 70.0 visual analogue scale (VAS). Following SVR, a reduction occurred in the proportion of patients with mobility problems (35% vs 24%, p = 0.012), pain/discomfort (60% vs 42%, p

Suggested Citation

  • Regina Juanbeltz & Iván Martínez-Baz & Ramón San Miguel & Silvia Goñi-Esarte & Juan Manuel Cabasés & Jesús Castilla, 2018. "Impact of successful treatment with direct-acting antiviral agents on health-related quality of life in chronic hepatitis C patients," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0205277
    DOI: 10.1371/journal.pone.0205277
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