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RV adaptation to increased afterload in congenital heart disease and pulmonary hypertension

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Listed:
  • Mieke M P Driessen
  • Tim Leiner
  • Gertjan Tj Sieswerda
  • Arie P J van Dijk
  • Marco C Post
  • Mark K Friedberg
  • Luc Mertens
  • Pieter A Doevendans
  • Repke J Snijder
  • Erik H Hulzebos
  • Folkert J Meijboom

Abstract

Background: The various conditions causing a chronic increase of RV pressure greatly differ in the occurrence of RV failure, and in clinical outcome. To get a better understanding of the differences in outcome, RV remodeling, longitudinal function, and transverse function are compared between patients with pulmonary stenosis (PS), those with a systemic RV and those with pulmonary hypertension (PH). Materials and methods: This cross-sectional study prospectively enrolled subjects for cardiac magnetic resonance imaging (CMR), functional echocardiography and cardiopulmonary exercise testing. The study included: controls (n = 37), patients with PS (n = 15), systemic RV (n = 19) and PH (n = 20). Statistical analysis was performed using Analysis of Variance (ANOVA) with posthoc Bonferroni. Results: PS patients had smaller RV volumes with higher RV ejection fraction (61.1±9.6%; p

Suggested Citation

  • Mieke M P Driessen & Tim Leiner & Gertjan Tj Sieswerda & Arie P J van Dijk & Marco C Post & Mark K Friedberg & Luc Mertens & Pieter A Doevendans & Repke J Snijder & Erik H Hulzebos & Folkert J Meijboo, 2018. "RV adaptation to increased afterload in congenital heart disease and pulmonary hypertension," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-17, October.
    • Handle: RePEc:plo:pone00:0205196
    DOI: 10.1371/journal.pone.0205196
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