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Factors predicting parametrial invasion in patients with early-stage cervical carcinomas

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  • Heng-Cheng Hsu
  • Yi-Jou Tai
  • Yu-Li Chen
  • Ying-Cheng Chiang
  • Chi-An Chen
  • Wen-Fang Cheng

Abstract

We aimed to identify factors predicting parametrial invasion in early-stage cervical cancer patients undergoing radical hysterectomy. We recruited women with invasive cervical cancer who underwent radical hysterectomy at a single medical institute from 2000–2011. The clinical and pathological characteristics and outcomes were retrospectively recorded, and the risk factors for parametrial invasion were analyzed. We enrolled 339 patients, including 7 with stage IA1 carcinomas, 10 with stage IA2, 266 with stage IB1, 39 with stage IB2, 14 with stage IIA1, and 3 with stage IIA2. The majority (237/339, 69.9%) had squamous cell carcinoma, while 32 (12.4%) had parametrial invasion. The 16 patients with stage IB1 tumors and parametrial invasion were older (55.9±9.5vs. 49.0±9.9 years, p = 0.005, Mann-Whitney U test), and had deeper cervical stromal invasion (9.59±4.87 vs. 7.47±5.48 mm, p = 0.048, Mann-Whitney U test), larger tumor size (2.32±1.15 vs. 1.74±1.14cm, p = 0.043, Mann-Whitney U test), higher incidences of lymphovascular space invasion (87.5% vs. 28.8%, p 2 cm,10% had parametrial invasion and 24.2% had lymph node metastasis compared with only 4% and 9.4% of stage IB1 patients with a tumor size

Suggested Citation

  • Heng-Cheng Hsu & Yi-Jou Tai & Yu-Li Chen & Ying-Cheng Chiang & Chi-An Chen & Wen-Fang Cheng, 2018. "Factors predicting parametrial invasion in patients with early-stage cervical carcinomas," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0204950
    DOI: 10.1371/journal.pone.0204950
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