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Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study

Author

Listed:
  • Berardino De Bari
  • Thomas Breuneval
  • Michele Zeverino
  • Sarah Godin
  • Letizia Deantonio
  • Christine Geldhof
  • Jean Bourhis
  • Nicklaus Schaefer
  • Raphaël Moeckli
  • John Prior
  • Mahmut Ozsahin

Abstract

Purpose: To study the potential of (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) in identifying the short-term variations of liver function after stereotactic body radiotherapy (SBRT) for liver cancers. Material and methods: We treated with SBRT 3 patients (pts) affected by a cholangiocarcinoma and 3 patient presenting liver metastases (3x15 Gy, 4 pts; 5x8 Gy, 1 pt; 6x5 Gy, 1 pt). All patients received HBS before and 3 months after SBRT, which were co-registered with the simulation CT-scan. Structures corresponding to isodoses from 10–90 Gy were created, with intervals of 10 Gy. Finally, the variations of the mean activity (MBq) in each isodose structure have been calculated. Then, a linear regression analysis was performed. Results: We showed a linear reduction of the activity, significantly related to the delivered dose (p

Suggested Citation

  • Berardino De Bari & Thomas Breuneval & Michele Zeverino & Sarah Godin & Letizia Deantonio & Christine Geldhof & Jean Bourhis & Nicklaus Schaefer & Raphaël Moeckli & John Prior & Mahmut Ozsahin, 2018. "Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0204013
    DOI: 10.1371/journal.pone.0204013
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