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Diagnostic accuracy of adding copeptin to cardiac troponin for non-ST-elevation myocardial infarction: A systematic review and meta-analysis

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  • Hyungoo Shin
  • Bo-Hyoung Jang
  • Tae Ho Lim
  • Juncheol Lee
  • Wonhee Kim
  • Youngsuk Cho
  • Chiwon Ahn
  • Kyu-Sun Choi

Abstract

Introduction: This study aimed to determine the diagnostic accuracy of adding copeptin to cardiac troponin (cTn) on admission to the emergency department (ED) for non-ST elevation myocardial infarction (NSTEMI) compared to cTn alone. Materials and methods: A literature search of MEDLINE, EMBASE, and the Cochrane Library was performed (search date: April 13, 2018). Primary studies were included if they accurately reported on patients with symptoms suggestive of acute myocardial infarction and measured both cTn alone and cTn with copeptin upon admission to the ED. The patients with evidence of ST elevation myocardial infarction were excluded. To assess the risk of bias for the included studies, the QUADAS-2 tool was used. Results: The study participants included a total of 7,998 patients from 14 observational studies. The addition of copeptin to cTn significantly improved the sensitivity (0.81 [0.74 to 0.87] vs. 0.92 [0.89 to 0.95], respectively, p

Suggested Citation

  • Hyungoo Shin & Bo-Hyoung Jang & Tae Ho Lim & Juncheol Lee & Wonhee Kim & Youngsuk Cho & Chiwon Ahn & Kyu-Sun Choi, 2018. "Diagnostic accuracy of adding copeptin to cardiac troponin for non-ST-elevation myocardial infarction: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0200379
    DOI: 10.1371/journal.pone.0200379
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