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Dual effects of leptin in perioperative gas exchange of morbidly obese patients

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  • Michele Carron
  • Giovanna Ieppariello
  • Gabriele Martelli
  • Giulia Gabellini
  • Mirto Foletto
  • Egle Perissinotto
  • Carlo Ori

Abstract

Leptin has shown positive effects on respiratory function in experimental settings. The role of leptin on perioperative respiratory function in morbidly obese patients has not been established. We performed a retrospective analysis of morbidly obese patients undergoing laparoscopic sleeve gastrectomy. Fasting serum leptin and interleukin (IL)-6 were measured preoperatively, and arterial blood gases were obtained pre- and postoperatively. Outcome variables were arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and differences in PaO2 and PaCO2 between pre- and postoperative values (ΔPaO2, ΔPaCO2; postoperative minus preoperative). Patients with lower (

Suggested Citation

  • Michele Carron & Giovanna Ieppariello & Gabriele Martelli & Giulia Gabellini & Mirto Foletto & Egle Perissinotto & Carlo Ori, 2018. "Dual effects of leptin in perioperative gas exchange of morbidly obese patients," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0199610
    DOI: 10.1371/journal.pone.0199610
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