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Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis

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  • Lijun Gu
  • Zhiyan Wang
  • Jing Zuo
  • Hongmei Li
  • Lin Zha

Abstract

Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity. The results of analysis were presented as hazard ratio (HR) or odds ratios (OR) with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients and NF-kB cellular localization within cancer cells were conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2>50% and P

Suggested Citation

  • Lijun Gu & Zhiyan Wang & Jing Zuo & Hongmei Li & Lin Zha, 2018. "Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0198223
    DOI: 10.1371/journal.pone.0198223
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