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Vasostatin-1: A novel circulating biomarker for ileal and pancreatic neuroendocrine neoplasms

Author

Listed:
  • Andrea Corsello
  • Luigi Di Filippo
  • Sara Massironi
  • Federica Sileo
  • Anna Dolcetta Capuzzo
  • Marco Gemma
  • Claudia Carlucci
  • Claudio Cusini
  • Barbara Colombo
  • Alice Dallatomasina
  • Giulia Maria Franchi
  • Angelo Corti
  • Marco Federico Manzoni

Abstract

Background: Chromogranin A (CgA) is a plasma biomarker widely used in the follow-up of patients with neuroendocrine neoplasms (NENs). However, its accuracy as a tumor biomarker is relatively low because plasma CgA can increase also in patients with other diseases or in subjects treated with proton-pump inhibitors (PPIs), a class of widely-used drugs. Methods: In the attempt to identify a more reliable biomarker for NENs, we investigated, by ELISA, the circulating levels of full-length CgA (CgA1-439) and of various CgA-derived fragments in 17 patients with ileal or pancreatic NENs, 10 healthy controls, and 21 healthy volunteers before and after treatment with PPIs. Results: Patients with ileal or pancreatic NENs showed increased plasma levels of total-CgA and CgA1-76 fragment (vasostatin-1, VS-1) compared to controls [median (25th-75th-percentiles); total-CgA: 1.85 nM (1.01–4.28) vs 0.75 nM (0.52–0.89), p = 0.004; VS-1: 2.76 nM (1.09–7.10) vs 0.29 nM (0.26–0.32), p

Suggested Citation

  • Andrea Corsello & Luigi Di Filippo & Sara Massironi & Federica Sileo & Anna Dolcetta Capuzzo & Marco Gemma & Claudia Carlucci & Claudio Cusini & Barbara Colombo & Alice Dallatomasina & Giulia Maria Fr, 2018. "Vasostatin-1: A novel circulating biomarker for ileal and pancreatic neuroendocrine neoplasms," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0196858
    DOI: 10.1371/journal.pone.0196858
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