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Expression and clinical significance of survivin in ovarian cancer: A meta-analysis

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  • Xiaoyan He
  • Kehu Yang
  • Hailin Wang
  • Xiaohong Chen
  • Huifang Wu
  • Liang Yao
  • Shouye Ma

Abstract

To assess the clinicopathological significance of survivin in ovarian carcinoma through this meta-analysis. PubMed, EMBASE, Web of Science, and The Cochrane Library databases were searched for relevant studies published through September, 2017. Included studies reported the case-control study of surviving expression with ovarian cancer and its clinicopathological characteristics. The quality assessment was performed according to the Newcastle–Ottawa Scale (NOS) for quality assessment of case–control studies. Statistical analysis was performed with the software Stata 12.0. Twelve eligible studies with a total of 1097 patients were included in this meta-analysis. Survivin overexpression was closely related to FIGO stage (I-II vs. III-IV) of ovarian carcinoma (odds ratio [OR] = 0.26,95% confidence interval [CI]:0.16,0.42),P

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  • Xiaoyan He & Kehu Yang & Hailin Wang & Xiaohong Chen & Huifang Wu & Liang Yao & Shouye Ma, 2018. "Expression and clinical significance of survivin in ovarian cancer: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0194463
    DOI: 10.1371/journal.pone.0194463
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