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Prognostic value of baseline, interim and end-of-treatment 18F-FDG PET/CT parameters in extranodal natural killer/T-cell lymphoma: A meta-analysis

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  • Hongxi Wang
  • Guohua Shen
  • Chong Jiang
  • Li Li
  • Futao Cui
  • Rong Tian

Abstract

Methods: We searched the PubMed, EMBASE, Cochrane Library and Medline databases for eligible articles. SUVmax, MTV, and TLG on B-PET/CT, DS on I-PET/CT and DS on E-PET/CT were regarded as efficacy data. Combined hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) were estimated using RevMan 5.3 software. Results: Nine trials with a total of 535 ENKTL patients were included. SUVmax, MTV and TLG on B-PET/CT were significantly associated with PFS with HRs of 2.78 (95%CI 1.54–5.03), 3.61 (95%CI 1.96–6.65) and 5.62 (95%CI 1.94–16.33), respectively, and with OS with HRs of 4.78 (95%CI 2.29–9.96), 3.20 (95%CI 1.55–6.60) and 7.76 (95%CI 1.79–33.58), respectively. For the DS on I-PET/CT, the HRs for PFS and OS were 5.15 (95%CI 2.71–9.80) and 5.80 (95%CI 2.28–14.73), respectively. Similarly, the DS on E-PET/CT was a significant predictor of PFS and OS with HRs of 3.65 (95%CI 2.13–6.26) and 3.32 (95%CI 1.79–6.15), respectively. Conclusion: Our results suggest that SUVmax, MTV, TLG on B-PET/CT, DS on I-PET/CT and DS on E-PET/CT may be significant prognostic indicators for PFS and OS in ENKTL patients. Moreover, TLG tends to be superior to SUVmax and MTV on B-PET/CT for predicting survival of ENKTL patients. Therefore, response monitoring and prognostication assessments based on multiple PET/CT parameters should be considered in the management of ENKTL patients.

Suggested Citation

  • Hongxi Wang & Guohua Shen & Chong Jiang & Li Li & Futao Cui & Rong Tian, 2018. "Prognostic value of baseline, interim and end-of-treatment 18F-FDG PET/CT parameters in extranodal natural killer/T-cell lymphoma: A meta-analysis," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0194435
    DOI: 10.1371/journal.pone.0194435
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