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Impact of 9p deletion and p16, Cyclin D1, and Myc hyperexpression on the outcome of anaplastic oligodendrogliomas

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  • Karine Michaud
  • Marie de Tayrac
  • Myreille D’Astous
  • Claudie Paquet
  • Peter Vincent Gould
  • Stéphan Saikali

Abstract

Objective: To study the presence of 9p deletion and p16, cyclin D1 and Myc expression and their respective diagnostic and prognostic interest in oligodendrogliomas. Methods: We analyzed a retrospective series of 40 consecutive anaplastic oligodendrogliomas (OIII) from a single institution and compared them to a control series of 10 low grade oligodendrogliomas (OII). Automated FISH analysis of chromosome 9p status and immunohistochemistry for p16, cyclin D1 and Myc was performed for all cases and correlated with clinical and histological data, event free survival (EFS) and overall survival (OS). Results: Chromosome 9p deletion was observed in 55% of OIII (22/40) but not in OII. Deletion was highly correlated to EFS (median = 29 versus 53 months, p

Suggested Citation

  • Karine Michaud & Marie de Tayrac & Myreille D’Astous & Claudie Paquet & Peter Vincent Gould & Stéphan Saikali, 2018. "Impact of 9p deletion and p16, Cyclin D1, and Myc hyperexpression on the outcome of anaplastic oligodendrogliomas," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-18, February.
    • Handle: RePEc:plo:pone00:0193213
    DOI: 10.1371/journal.pone.0193213
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    1. Céline Duval & Marie de Tayrac & Karine Michaud & Florian Cabillic & Claudie Paquet & Peter Vincent Gould & Stéphan Saikali, 2015. "Automated Analysis of 1p/19q Status by FISH in Oligodendroglial Tumors: Rationale and Proposal of an Algorithm," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-17, July.
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