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Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations

Author

Listed:
  • Harsh Sheth
  • Emma Northwood
  • Cornelia M Ulrich
  • Dominique Scherer
  • Faye Elliott
  • Jennifer H Barrett
  • David Forman
  • C Roland Wolf
  • Gillian Smith
  • Michael S Jackson
  • Mauro Santibanez-Koref
  • Robert Haile
  • Graham Casey
  • Mark Jenkins
  • Aung Ko Win
  • John L Hopper
  • Loic Le Marchand
  • Noralane M Lindor
  • Stephen N Thibodeau
  • John D Potter
  • John Burn
  • D Timothy Bishop

Abstract

Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin’s chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two large population-based case-control datasets, the UK-Leeds Colorectal Cancer Study Group and the NIH-Colon Cancer Family Registry, having a combined total of 3325 cases and 2262 controls. The aim was to assess 42 candidate SNPs in 15 genes whose association with colorectal cancer risk was putatively modified by aspirin use, in the literature. Log odds ratios (ORs) and standard errors were estimated for each dataset separately using logistic regression adjusting for age, sex and study site, and dataset-specific results were combined using random effects meta-analysis. Meta-analysis showed association between SNPs rs6983267, rs11694911 and rs2302615 with CRC risk reduction (All P

Suggested Citation

  • Harsh Sheth & Emma Northwood & Cornelia M Ulrich & Dominique Scherer & Faye Elliott & Jennifer H Barrett & David Forman & C Roland Wolf & Gillian Smith & Michael S Jackson & Mauro Santibanez-Koref & R, 2018. "Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-17, February.
    • Handle: RePEc:plo:pone00:0192223
    DOI: 10.1371/journal.pone.0192223
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