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The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies

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  • Hui Luo
  • Xiaohui Xu
  • Miaomiao Ye
  • Bo Sheng
  • Xueqiong Zhu

Abstract

Background: The prognostic role of human epidermal growth factor receptor 2 (HER2) in ovarian cancer has been investigated in previous studies, but the results remain controversial. Here we present a meta-analysis to systematically review the association between HER2 expression and ovarian cancer prognosis. Method: Observational studies published until July 2017 were searched in Pubmed, Embase, and Cochrane library databases. Hazard ratios (HRs) for survival with 95% confidence intervals (CIs), subgroup analyses, publication bias and sensitivity analyses were implemented under a standard manner. Estimates of overall survival (OS), progress-free survival (PFS) and disease-free survival (DFS) were weighted and pooled using Der Simonian-Laird random-effect model. Result: Thirty-four studies that include 5180 ovarian cancer patients were collected for analysis. Expression of HER2 was negatively correlated with clinical prognosis of overall survival (HR = 1.57, 95% CI: 1.31 to 1.89, P

Suggested Citation

  • Hui Luo & Xiaohui Xu & Miaomiao Ye & Bo Sheng & Xueqiong Zhu, 2018. "The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-16, January.
    • Handle: RePEc:plo:pone00:0191972
    DOI: 10.1371/journal.pone.0191972
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