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Do blast induced skull flexures result in axonal deformation?

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  • Harsha T Garimella
  • Reuben H Kraft
  • Andrzej J Przekwas

Abstract

Subject-specific computer models (male and female) of the human head were used to investigate the possible axonal deformation resulting from the primary phase blast-induced skull flexures. The corresponding axonal tractography was explicitly incorporated into these finite element models using a recently developed technique based on the embedded finite element method. These models were subjected to extensive verification against experimental studies which examined their pressure and displacement response under a wide range of loading conditions. Once verified, a parametric study was developed to investigate the axonal deformation for a wide range of loading overpressures and directions as well as varying cerebrospinal fluid (CSF) material models. This study focuses on early times during a blast event, just as the shock transverses the skull (

Suggested Citation

  • Harsha T Garimella & Reuben H Kraft & Andrzej J Przekwas, 2018. "Do blast induced skull flexures result in axonal deformation?," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-24, March.
    • Handle: RePEc:plo:pone00:0190881
    DOI: 10.1371/journal.pone.0190881
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