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Relation of body mass index to risk of developing inflammatory bowel disease amongst women in the Danish National Birth Cohort

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  • Michael Mendall
  • Maria Christina Harpsøe
  • Devinder Kumar
  • Mikael Andersson
  • Tine Jess

Abstract

Background: Crohn’s disease (CD) has traditionally been associated with weight loss and low BMI, yet paradoxically obesity has recently been suggested as a risk factor for CD, but not for ulcerative colitis (UC). We therefore hypothesized that the relation between BMI and CD is U shaped. Aim: To conduct a large population-based prospective cohort study of BMI and later risk of IBD, taking age at IBD diagnosis into account. Methods: A cohort of 74,512 women from the Danish National Birth Cohort, with BMI measured pre-pregnancy and 18 months after delivery, was followed for 1,022,250 person-years for development of IBD, according to the Danish National Patient Register. Associations were tested by Cox regression. Results: Overweight subjects (25≤BMI

Suggested Citation

  • Michael Mendall & Maria Christina Harpsøe & Devinder Kumar & Mikael Andersson & Tine Jess, 2018. "Relation of body mass index to risk of developing inflammatory bowel disease amongst women in the Danish National Birth Cohort," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-15, January.
    • Handle: RePEc:plo:pone00:0190600
    DOI: 10.1371/journal.pone.0190600
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