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Mobile direct observation of therapy (MDOT) - A rapid systematic review and pilot study in children with asthma

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  • Michael D Shields
  • Fahad ALQahtani
  • Michael P Rivey
  • James C McElnay

Abstract

We describe, for the first time, the use of a mobile device platform for remote direct observation of inhaler use and technique. The research programme commenced with a rapid systematic review of mobile device (or videophone) use for direct observation of therapy (MDOT). Ten studies (mainly pilots) were identified involving patients with tuberculosis, sickle cell disease and Alzheimer's disease. New studies are ongoing (ClinicalTrials.gov website) in TB, stroke, sickle cell disease, HIV and opioid dependence. Having identified no prior use of MDOT in inhaler monitoring, we implemented a feasibility study in 12 healthy volunteer children (2–12 years; 8 females and 4 males) over a period of 14 days, with twice daily video upload of their 'dummy' inhaler use. Two children uploaded 100% of the requested videos, with only one child having an inhaler upload rate of 0.05), however, mean fraction of exhaled nitric oxide (FeNO) values normalised (mean 38.7 to 19.3ppm) and mean Asthma Control Test values improved (13.1 to mean 17.8). Feedback from participants was positive. Overall the findings open up a new paradigm in device independent (can be used for any type of inhaler device) monitoring, providing a platform for evaluating / improving inhaler use at home.

Suggested Citation

  • Michael D Shields & Fahad ALQahtani & Michael P Rivey & James C McElnay, 2018. "Mobile direct observation of therapy (MDOT) - A rapid systematic review and pilot study in children with asthma," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-24, February.
    • Handle: RePEc:plo:pone00:0190031
    DOI: 10.1371/journal.pone.0190031
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