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Systematic review and meta-analysis of traditional Chinese medicine in the treatment of constipation-predominant irritable bowel syndrome

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  • Dan-yan Li
  • Yun-kai Dai
  • Yun-zhan Zhang
  • Meng-xin Huang
  • Ru-liu Li
  • Jia Ou-yang
  • Wei-jing Chen
  • Ling Hu

Abstract

Aim: This meta-analysis analyzed the efficacy and safety of traditional Chinese medicine (TCM) for the treatment of irritable bowel syndrome with constipation (IBS-C). Methods: We searched seven electronic databases for randomized controlled trials investigating the efficacy of TCM in the treatment of IBS-C. The search period was from inception to June 1, 2017. Eligible RCTs compared TCM with cisapride and mosapride. Article quality was evaluated with the Cochrane Risk Bias Tool in the Cochrane Handbook by two independent reviewers. Begg’s test was performed to evaluate publication bias. Review Manager 5.3 and Stata 12.0 were used for analyses. Results: Eleven eligible studies comprising a total of 906 participants were identified. In the primary outcome, TCM showed significant improvement in overall clinical efficacy compared with cisapride and mosapride (odds ratio [OR] = 4.00; 95% confidence interval [CI]: 2.74,5.84; P

Suggested Citation

  • Dan-yan Li & Yun-kai Dai & Yun-zhan Zhang & Meng-xin Huang & Ru-liu Li & Jia Ou-yang & Wei-jing Chen & Ling Hu, 2017. "Systematic review and meta-analysis of traditional Chinese medicine in the treatment of constipation-predominant irritable bowel syndrome," PLOS ONE, Public Library of Science, vol. 12(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0189491
    DOI: 10.1371/journal.pone.0189491
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    References listed on IDEAS

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    1. Ya Xiao & Yanyan Liu & Shaohui Huang & Xiaomin Sun & Yang Tang & Jingru Cheng & Tian Wang & Fei Li & Yuxiang Kuang & Ren Luo & Xiaoshan Zhao, 2015. "The Efficacy of Shugan Jianpi Zhixie Therapy for Diarrhea-Predominant Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-12, April.
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    Cited by:

    1. Yuchao Le & Shihua Cao & Mengxin Wang & Danni He & Yanfei Chen & Beiying Qian, 2022. "Effect of Fresh Dendrobe Juice Consumption on Senile Habitual Constipation for Older People: A Four-Week Randomized Controlled Trial," Sustainability, MDPI, vol. 14(6), pages 1-12, March.

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