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Factors related to acupuncture response in patients with chronic severe functional constipation: Secondary analysis of a randomized controlled trial

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  • Xingyue Yang
  • Yan Liu
  • Bing Liu
  • Liyun He
  • Zhishun Liu
  • Yanshi Yan
  • Jia Liu
  • Baoyan Liu

Abstract

Background: Acupuncture has been demonstrated to be effective and safe for chronic severe functional constipation (CSFC). However, which patients with CSFC will have a better response to acupuncture remains unclear. Objective: To explore factors related to acupuncture response in patients with CSFC. Methods: We performed a secondary analysis of a previous multicenter randomized controlled trial consisting of a 2-week run-in period, 8-week treatment, and 12-week follow-up without treatment in which patients with CSFC were randomly allocated to an electroacupuncture group or a sham electroacupuncture group. Responders were defined as participants with an increase of at least one complete spontaneous bowel movement (CSBM) in week 20 compared with the baseline period. The CSBM responder rate in both groups was described, and the baseline characteristics of participants potentially related to acupuncture response were mainly analyzed using logistic regression analysis with bootstrapping techniques. Results: A total of 1021 participants were analyzed in this study, of whom 516 (50.5%) were classified as responders. The CSBM responder rate in week 20 was significantly greater in the electroacupuncture group than in the sham electroacupuncture group (62.9% vs. 37.9%, respectively; P

Suggested Citation

  • Xingyue Yang & Yan Liu & Bing Liu & Liyun He & Zhishun Liu & Yanshi Yan & Jia Liu & Baoyan Liu, 2017. "Factors related to acupuncture response in patients with chronic severe functional constipation: Secondary analysis of a randomized controlled trial," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-9, November.
    • Handle: RePEc:plo:pone00:0187723
    DOI: 10.1371/journal.pone.0187723
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