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Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo

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  • Joshua M Moreau
  • Selena Cen
  • Alexandra Berger
  • Caren Furlonger
  • Christopher J Paige

Abstract

Immature B cells are the first B cell progenitors to express a fully formed B cell receptor and are therefore subject to extensive selection processes that act to mitigate the emergence of autoreactive clones. While it is well appreciated that most B cell generation in the bone marrow is highly dependent on access to molecules present in the local milieu, the existence of extrinsically provided factors that modulate immature B cell biology is ambiguous. Nonetheless, a population of CD49b+CD90lo cells has demonstrated in vitro potential to promote immature B cell survival. Using a mouse basophil reporter strain we confirmed the identity of these CD49b+CD90lo supportive cells as basophils. However, analysis of bone marrow B cell populations following lineage specific basophil depletion demonstrates that basophils do not have a significant role in vivo in modulating immature B cell biology during steady-state conditions.

Suggested Citation

  • Joshua M Moreau & Selena Cen & Alexandra Berger & Caren Furlonger & Christopher J Paige, 2017. "Bone marrow basophils provide survival signals to immature B cells in vitro but are dispensable in vivo," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0185509
    DOI: 10.1371/journal.pone.0185509
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