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Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers

Author

Listed:
  • Yoko Kubo
  • Takahiro Imaizumi
  • Masahiko Ando
  • Masahiro Nakatochi
  • Yoshinari Yasuda
  • Hiroyuki Honda
  • Yachiyo Kuwatsuka
  • Sawako Kato
  • Kyoko Kikuchi
  • Takaaki Kondo
  • Masamitsu Iwata
  • Toru Nakashima
  • Hiroshi Yasui
  • Hideki Takamatsu
  • Hiroshi Okajima
  • Yasuko Yoshida
  • Shoichi Maruyama

Abstract

Background: Several single nucleotide polymorphisms (SNPs) have been implicated in the predisposition to chronic kidney disease (CKD). Atherosclerotic disease is deeply involved in the incidence of CKD; however, whether SNPs related to arteriosclerosis are involved in CKD remains unclear. This study aimed to identify SNPs associated with CKD and to examine whether risk allele accumulation is associated with CKD. Methods: We conducted a cross-sectional study using data of 4814 male workers to examine the association between estimated glomerular filtration rate (eGFR) and 59 candidate polymorphisms (17 CKD, 42 atherosclerotic diseases). We defined the genetic risk score (GRS) as the total number of risk alleles that showed a significant association in this analysis and examined the relationship with CKD (eGFR

Suggested Citation

  • Yoko Kubo & Takahiro Imaizumi & Masahiko Ando & Masahiro Nakatochi & Yoshinari Yasuda & Hiroyuki Honda & Yachiyo Kuwatsuka & Sawako Kato & Kyoko Kikuchi & Takaaki Kondo & Masamitsu Iwata & Toru Nakash, 2017. "Association between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0185476
    DOI: 10.1371/journal.pone.0185476
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