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D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

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  • Saeed Sadigh-Eteghad
  • Alireza Majdi
  • Sarah K McCann
  • Javad Mahmoudi
  • Manouchehr S Vafaee
  • Malcolm R Macleod

Abstract

Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the d-galactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing.

Suggested Citation

  • Saeed Sadigh-Eteghad & Alireza Majdi & Sarah K McCann & Javad Mahmoudi & Manouchehr S Vafaee & Malcolm R Macleod, 2017. "D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0184122
    DOI: 10.1371/journal.pone.0184122
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