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Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women

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  • Wan-Yu Huang
  • I-Lun Hsin
  • Dar-Ren Chen
  • Chia-Chu Chang
  • Chew-Teng Kor
  • Ting-Yu Chen
  • Hung-Ming Wu

Abstract

Introduction: Hot flashes have been postulated to be linked to systemic inflammation. This study aimed to investigate the relationship between hot flashes, pro-inflammatory factors, and leukocytes in healthy, non-obese postmenopausal women. Participants and design: In this cross-sectional study, a total of 202 women aged 45–60 years were stratified into one of four groups according to their hot-flash status: never experienced hot flashes (Group N), mild hot flashes (Group m), moderate hot flashes (Group M), and severe hot flashes (Group S). Variables measured in this study included clinical parameters, hot flash experience, leukocytes, and fasting plasma levels of nine circulating cytokines/chemokines measured by using multiplex assays. Multiple linear regression analysis was used to evaluate the associations of hot flashes with these pro-inflammatory factors. Settings: The study was performed in a hospital medical center. Results: The mean values of leukocyte number were not different between these four groups. The hot flash status had a positive tendency toward increased levels of circulating IL-6 (P-trend = 0.049), IL-8 (P-trend

Suggested Citation

  • Wan-Yu Huang & I-Lun Hsin & Dar-Ren Chen & Chia-Chu Chang & Chew-Teng Kor & Ting-Yu Chen & Hung-Ming Wu, 2017. "Circulating interleukin-8 and tumor necrosis factor-α are associated with hot flashes in healthy postmenopausal women," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0184011
    DOI: 10.1371/journal.pone.0184011
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