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Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis

Author

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  • Ruey Chen
  • Pi-Tuan Chan
  • Hsin Chu
  • Yu-Cih Lin
  • Pi-Chen Chang
  • Chien-Yu Chen
  • Kuei-Ru Chou

Abstract

Background: This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive functions, behavioral and psychological symptoms in dementia (BPSD), and global functions. Methods: PubMed, Medline, Embase, PsycINFO, and Cochrane databases were used to search for English and non-English articles for inclusion in the meta-analysis to evaluate the effect size and incidence of adverse drug reactions of different treatments. Results: Compared with patients who received donepezil alone, those who received donepezil in combination with memantine exhibited limited improvements in cognitive functions (g = 0.378, p

Suggested Citation

  • Ruey Chen & Pi-Tuan Chan & Hsin Chu & Yu-Cih Lin & Pi-Chen Chang & Chien-Yu Chen & Kuei-Ru Chou, 2017. "Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0183586
    DOI: 10.1371/journal.pone.0183586
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    Cited by:

    1. Keisuke Hanada & Tomoyuki Sugimoto, 2023. "Inference using an exact distribution of test statistic for random-effects meta-analysis," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 75(2), pages 281-302, April.

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