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Hypercholesterolemia induced cerebral small vessel disease

Author

Listed:
  • Peter Kraft
  • Michael K Schuhmann
  • Cornelia Garz
  • Solveig Jandke
  • Daniela Urlaub
  • Stine Mencl
  • Alma Zernecke
  • Hans-Jochen Heinze
  • Roxana O Carare
  • Christoph Kleinschnitz
  • Stefanie Schreiber

Abstract

Background: While hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear. We thus aimed to understand the detailed relationship between hypercholesterolemia and CSVD using the well described Ldlr-/- mouse model. Methods: We used Ldlr-/- mice (n = 16) and wild-type (WT) mice (n = 15) at the age of 6 and 12 months. Ldlr-/- mice develop high plasma cholesterol levels following a high fat diet. We analyzed cerebral capillaries and arterioles for intravascular erythrocyte accumulations, thrombotic vessel occlusions, blood-brain barrier (BBB) dysfunction and microbleeds. Results: We found a significant increase in the number of erythrocyte stases in 6 months old Ldlr-/- mice compared to all other groups (P

Suggested Citation

  • Peter Kraft & Michael K Schuhmann & Cornelia Garz & Solveig Jandke & Daniela Urlaub & Stine Mencl & Alma Zernecke & Hans-Jochen Heinze & Roxana O Carare & Christoph Kleinschnitz & Stefanie Schreiber, 2017. "Hypercholesterolemia induced cerebral small vessel disease," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0182822
    DOI: 10.1371/journal.pone.0182822
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