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The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis

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  • Rongyuan Zhuang
  • Song Li
  • Qian Li
  • Xi Guo
  • Feng Shen
  • Hong Sun
  • Tianshu Liu

Abstract

KRAS mutation has been found in various types of cancer. However, the prognostic value of KRAS mutation in cell-free DNA (cfDNA) in cancer patients was conflicting. In the present study, a meta-analysis was conducted to clarify its prognostic significance. Literature searches of Cochrane Library, EMBASE, PubMed and Web of Science were performed to identify studies related to KRAS mutation detected by cfDNA and survival in cancer patients. Two evaluators reviewed and extracted the information independently. Review Manager 5.3 software was used to perform the statistical analysis. Thirty studies were included in the present meta-analysis. Our analysis showed that KRAS mutation in cfDNA was associated with a poorer survival in cancer patients for overall survival (OS, HR 2.02, 95% CI 1.63–2.51, P

Suggested Citation

  • Rongyuan Zhuang & Song Li & Qian Li & Xi Guo & Feng Shen & Hong Sun & Tianshu Liu, 2017. "The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-15, August.
    • Handle: RePEc:plo:pone00:0182562
    DOI: 10.1371/journal.pone.0182562
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